Early delayed hypersensitivity responses in tuberculin skin tests after heavy occupational exposure to tuberculosis.

Early delayed hypersensitivity responses in tuberculin skin tests after heavy occupational exposure to tuberculosis.

The early (six hours) reaction to tuberculin skin testing was studied in 33 Indonesian hospital workers with frequent occupational exposure to M tuberculosis and compared with responses maximal at the usual time (48 hours) in factory workers, from the same locality but with only occasional occupational exposure, to determine the nature of the early reaction. The early reaction had the same gene...

CD14-159C/T polymorphism in the development of delayed skin hypersensitivity to tuberculin

The skin tuberculin test (TST), an example of a delayed-type hypersensitivity (DTH) reaction, is based on measuring the extent of skin induration to mycobacterial tuberculin (PPD). Little is known about the genetic basis of TST reactivity, widely used for diagnosing TB infection. The study investigated the relationship of the single base change polymorphic variants in CD14 gene (CD14(-159C/T)) ...

Tuberculosis and Tuberculin Tests in Subhuman Primates *

The incidence of tuberculosis has always been high among monkeys and anthropoid apes in captivity in zoological gardens and research colonies. More recently it has been recognized that the disease is a serious menace both to the welfare of the animals and to that of human contacts. About 25 per cent of more than 2000 monkeys and anthropoids used by the Laboratory of Physiology of the Yale Unive...

Comparing Interferon-Gamma Release Assays to Tuberculin Skin Test in Thai Children with Tuberculosis Exposure

BACKGROUND Data on the performance of interferon-gamma release assays (IGRAs), QuantiFERON TB Gold In-tube (QFNGIT) and T-Spot.TB, in diagnosing tuberculosis (TB) are limited in Southeast Asia. This study aims to compare the performances of the two IGRAs and TST in Thai children with recent TB exposure. METHODS This multicenter, prospective study enrolled children with recent exposure to acti...

Serious allergic reactions following tuberculin skin tests.